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We did not observe any in vivo changes in cardiomyocyte H 2 O 2 levels, probably due to increased antioxidant defence [9], which may be driven by eukaryotic initiation factor 2 alpha subunit (eIF2)/activating transcription factor 4 (ATF4)-mediated upregulation of one-carbon metabolism and a subsequent increase in glutathione production [15]
Medeiros JFP, de Oliveira Borges MV, Soares AA, et al
Sulfa drugs and the skin
Studies have demonstrated that FOXO4-DRI modulates multiple regulatory pathways, including insulin signaling, cell cycle control, and oxidative stress response
[Studies on glutathione: H2O2-oxidoreductase (glutathione peroxidase)]
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