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Result: significant muscle loss (20-30% of weight lost)

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Comparisons with proteomic profiles identified in the deCODE cohort (an observational cohort of 35,559 Icelanders 23 ) allowed us to examine where semaglutide treatment might have benefits and assess its potential impact on a wide range of conditions, including CVD (atherosclerotic myocardial infarction and reduced ejection fraction on an echocardiogram)

Drug interactions: Avoid concomitant use with antibiotics, chemotherapy, or substances that increase oxidative stress, such as alcohol or recreational drugs

There are no current recommendations by ICMR, but studies have shown beneficial effects using the dose mentioned below