Cycling is non-negotiable
Given the ancient origin of the Ca 2+ -based signaling, which evolutionary developed earlier than the mitochondrial apoptotic toolkit whose emergence cannot be dated back to the times earlier than eukaryogenesis and acquisition of an endosymbiotic mitochondrion, it can be assumed that the Ca 2+ toolkit takes over a key role in cell death signaling in terminally differentiated mitochondria-free erythrocytes
Gelhorn HL, Bacci ED, Poon JL, Boye KS, Suzuki S, Babineaux SM
I do not consider that an effective treatment
Neurological Risk: Unbound free copper generates reactive oxygen species via Fenton chemistry
This makes topical products more suitable for specific areas such as the face, hands, feet, or knuckles, where uneven tone is more common