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A low dead space syringe retaining 0.003 ml per injection at weekly frequency wastes 0.156 ml per year

p53 is activated upon genotoxic and oxidative stress, which activates AMP-responsive protein kinase (AMPK) through the tuberous sclerosis (TSC) 1/TSC2 complex and inhibits mTOR activity to promote autophagy

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So, in summary: FOXO4-DRI appears to represent the next-generation senolytic, offering improved specificity, but it is still earlier stage than many small-molecule senolytics or repurposed drug combinations