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The proposed mechanism is that MOTS-c interacts with the STAT3 transcription factor via its putative SH2 binding motif (YIFY region), thereby reducing STAT3s transcriptional activity and promoting myotube formation

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Gastrointestinal effects such as diarrhoea can accelerate intestinal transit, preventing bile's natural conversion from green to brown

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Sleep schedules vary less than waking schedules for most people, and GH pulse timing is more stable across individuals than cortisol peak timing

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