doi: 10.2174/1570159x13666160502153022
Patients using semaglutide can, in some cases, achieve a reduction in body weight of around 10-20% over a year, which is substantial compared to other weight loss medications
in fact, research indicates they may offer benefits for certain liver conditions, particularly non-alcoholic fatty liver disease (NAFLD), although they are not specifically licensed for treating liver conditions

For those with hypermobility and EDS specifically, Id flag the following as the minimum due diligence before starting these medications: A thorough GI history and ideally gastric emptying assessment if theres any existing dysmotility Baseline muscle mass measurement (DEXA or similar) given the sarcopenia risk A clear plan for high-protein diet and resistance-based exercise to mitigate muscle loss Baseline bone density if theres any existing concern Consideration of the nutritional picture specific to hypermobility, since these drugs can affect appetite and nutrient absorption A conversation specifically about MCAS if thats a feature of your presentation The medication options for hypermobility and EDS are limited and often unsatisfying, and its entirely understandable why people are looking at something new with genuine curiosity

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It minimizes loss and enhances safety