Notably, RSL3 is widely used as a pharmacological inhibitor of GPX4, although studies in cell-free systems suggest that it may also exhibit inhibitory activity toward thioredoxin reductase 1 (TXNRD1), a key NADPH-dependent antioxidant enzyme that maintains thioredoxin-mediated redox homeostasis
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NAC supplementation (600 mg/day) has been shown to improve flow-mediated dilation in patients with chronic heart failure in a small RCT (Andrews et al., J Am Coll Cardiol, 2001) [65]
2020 safety paper is considered essential reading for any researcher evaluating this compounds translational potential
Rates of diabetes also tended to be lower (33.3% vs
