Upregulation of RAGE was also found in such immune cells as neutrophils, monocytes/macrophages, lymphocytes, dendritic cells, where its activation resulted in the induction of expression of NF-B-regulated genes encoding proinflammatory cytokines, chemokines, and adhesion molecules (15, 102104)
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10.1016/j.dnarep.2009.08.003 167 JohnsonW
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This is to: a) rule out underlying issues