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Concomitant use with insulin or an insulin secretagogue may increase the risk of hypoglycemia, including severe hypoglycemia, and a lower dose of insulin or insulin secretagogue may be necessary
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NCT01885208
Genetically-predicted GLP1R expression (the target of GLP-1 RAs) showed an inverse association with background [odds ratio (OR)=0.83, 95% CI, 0.710.97] and severe nonproliferative DR (OR=0.72, 95% CI, 0.530.98), and a non-significant association with overall (OR=0.97, 95% CI, 0.921.03) and proliferative DR (OR=0.98, 95% CI, 0.911.05)
Kitamura K, et al
Patients with severe symptoms, inability to maintain hydration, or significant weight loss may require hospitalization for intravenous fluids, nutritional support, and symptom management
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