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While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)
Testosterone replacement therapy is exact
Intraoral malignant melanotic schwannoma
Emerging evidence suggests that MetS contributes to pain catastrophizing, with obesity acting as a key amplifier of pain perception in inflammatory diseases such as PsA (73)
Researchers should always be wary of any post-hoc theories to justify an observed correlation as practical experience has shown that researchers can easily suggest a plausible rationale
Um, I also think it works really well because my patients generally are inflamed
