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The metabolic plasticity of cancer is not restricted only to cancer cells but extends throughout the TME (184, 185), as seen in CAFs that secrete lactate, lung mesenchymal-derived cells that transfer lipids, suppressing the functioning of NK cells, and arginine-depleting collagen-producing TAMs, leading to the suppression of CD8 + T cell functions
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Many adults remain stable on 1,000 mcg once monthly, though dose intervals can be adjusted according to serum markers
It has been associated with reduced fatigue, improved mood and enhanced cognitive function, supporting overall vitality in aging individuals
