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As an antioxidant, glutathione helps to reduce oxidative damage caused by free radicals, which can lead to fatigue

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In addition, the only known transporter that places GSH in the ELF is CFTR, the gene defective in cystic fibrosis [42]

111,112,113,114,115,116 Critically, multiple cohorts consistently identified the significant association between ACE I/D polymorphism and HAPE susceptibility

In stark contrast, significant chromosome damage was evident upon treatment with the DNA crosslinking agent MMC, thus suggesting that when DNA repair is functional, FA might be causing cell death by damaging other cellular components rather than DNA