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P450 reductase catalysis produces superoxide radicals, which can, in the presence of superoxide dismutase and Fe 3+ , form highly reactive hydroxyl radicals capable of damaging virtually all macromolecules

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Huerlimann et al., 2022), although in many cases these genes may not be functional or have been incorrectly annotated as CRCN

Apoptosis of uterine leiomyoma cells was also stimulated by the expression of caspase-3, an important mediator for apoptosis, and by caspase-9, an initiator of apoptosis (Malik et al., 2009)