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is the biocatalyst of choice and fermentation substrates such as corn flour, cassava starch or flour, oil palm sap, or glucose, account for over 70% of the production cost (Gu et al

189 Further, ME1 treated with the inhibitor (piperazine-1-pyrrolidine-2,5-dione) has little effect on normal rat intestinal epithelial cells but strongly suppresses human CRC cell growth by targeting ME1 NADP + -binding site and reducing the NADPH level