Pickart stated that GHK-Cu has a favorable safety profile, highlighting that there is no indication that it causes side effects in test subjects [2]: The molecule is very safe and no issues have ever arisen during its use as a skin cosmetic or in human wound healing studies. In a 2018 review based on new genetic data, he reiterated that all biological actions associated with GHK appear to be health positive. He pointed to over four decades of GHK research encompassing cell, tissue, and animal studies, also noting the peptides inclusion in commercial anti-aging and cosmetic products such as creams, liposomes, and dermal patches [1]
Beyond pigmentation, glutathione functions as a powerful antioxidant in skin tissue
Local GHK-Cu exposure in a rat wound-chamber model
Balancing the structural robustness required to prevent premature drug leakage in systemic circulation with the necessity for stimuli-responsive disassembly at the tumor site remains a critical engineering challenge
However, the team classed the quality of the evidence as low
Nicholas SB, Correa-Rotter R, Desai NR, et al