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Patients presented the largest weight loss reported to date with that drug class, prompting Novo Nordisk to conduct additional studies on semaglutide and other GLP-1Ra in people living with obesity (PwO) [18, 19]
Recently our group has demonstrated that indeed OEA is just a partial agonist of GPR119, and the biological ligand of this receptor is the lysophospholipid Oleoyl-Lysophosphatidylinositol (Oleoyl-LPI) ( in vitro and ex-vivo from intestines of wild type, but not GPR119 deficient mice
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