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Tirzepatide has been shown to reduce how much oral contraceptives the body absorbs by around 20% (8)

In nature, it protects the stomach lining from strong acid (think of gastric juice )

The NHS pathway under NICE TA1026 currently restricts tirzepatide to a BMI of 40 or above with four of five qualifying conditions, with the threshold widening over the next 12 years

However, chronic licorice consumption can lead to serious side effects due to the presence of considerable quantities of glycyrrhizin, which causes severe hypokalemia and hypertension

Its worth noting that in the context of drug delivery, the starting point for decay is when the max concentration of the drug from a single dose is reached

or if they develop signs of more serious adverse effects such as severe abdominal pain (which may indicate pancreatitis), symptoms of gallbladder disease, visual changes, severe allergic reactions, or symptoms of thyroid nodules