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Purifications were conducted by preparative RP-HPLC, eluting with a linear gradient (20 ml min 1 ) and using a binary solvent system consisting of H 2 O:MeCN:TFA (buffer A, 95:5:0.1

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The three interaction axes that matter for GLP-1 drugs additive hypoglycemia, additive GI side effects, and delayed gastric emptying altering absorption of narrow-therapeutic-index drugs are all absent here