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The pattern is that both are GI-forward drugs, but retatrutides glucagon activity adds a cardiovascular consideration (heart rate) that cagrilintides amylin mechanism does not, and the same potency that produces retatrutides larger weight loss is associated, in indirect analyses, with a heavier adverse-event load
For years, humans have tried diets, exercise regimens, and lifestyle adjustments to achieve better results
But based on mechanism and phase 2 observations: retatrutide likely has a somewhat more demanding titration phase, with potentially greater efficacy as the reward
As a result, "the exact mechanism of the way these medications work is not fully established," he says
BMJ 339(nov24 1):b4567 Titze J (2015) A different view on sodium balance
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