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Within this mechanistic framework, natural compounds with antioxidant and anti-inflammatory properties, including vitamins C and E, glutathione precursors, CoQ10, L-carnosine, polyphenols including quercetin, resveratrol, and curcumin, and saffron metabolites like crocin and safranal show biological plausibility and preliminary efficacy on biochemical and behavioral endpoints

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A phase I clinical trial is ongoing to evaluate JNJ-64619178 in advanced solid tumors (NCT03573310)

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Intensive and continuous pericellular claudin-5 staining was observed in the model and the shape of the hECs also indicated a typical brain endothelial cell layer (Fig

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