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Mechanism of action: How GLP-1s work in the body This graph provides a high level overview of the roles of naturally occurring GLP-1 in the body: (1) When food is consumed, it begins to break down in the stomach and small intestine

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Approved obesity drugs have improved upon body weight reduction, but, in part, at the expense of lean muscle

48 In vivo models have also shown that GLP-1 RAs positively modulate cardiac remodelling with less cardiac hypertrophy and fibrosis

doi: 10.3109/10826084.2015.1082595