The US Food and Drug Administration approved this first-in-class medication for the management of type 2 diabetes (T2D) in 2022 [2], for the reduction of excess weight in adults with obesity or overweight in 2023 [3], and for moderate-to-severe obstructive sleep apnea (OSA) in people with obesity in 2024 [4]
Public Health Policy Implications
It is important to try and increase fiber and polyphenols where tolerated to help feed up the beneficial bacteria associated with improved motility and methane reduction
GLP-1 is secreted by intestinal L-cells in response to food intake and promotes insulin secretion from pancreatic -cells, thereby playing a key role in regulating the blood glucose concentration 20,21,22,23
Journal of General Internal Medicine
Without being bound to copper, GHK has been shown to be a quencher of cytotoxic end products of lipid peroxidation such as ,-4-hydroxy-trans-2-nonenal and acrolein, which can be associated with severe pathologies such as diabetes and neurodegenerative disease [18- 19]