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Translational superiority of GLP-1R/GCGR dual agonism versus GLP-1R on the body weight benefit was later demonstrated in obese rhesus monkeys (47, 48) and confirmed by other groups (49)
After transitioning to semaglutide 2.4 mg weekly (the Wegovy dose) , she developed skin dysesthesia within a few weeks
Patients didnt just lose a couple of stubborn pounds
In many of the clinical trials comparing GLP-1RAs with sitagliptin, more than 50% of the participants treated with GLP-1RA achieved this weight loss benchmark (102)
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