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Oral forms have been studied but results are variable
Cancer Genome Atlas Research Network Integrated genomic characterization of oesophageal carcinoma
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Skipping moisturizer can make the skin produce more oil to compensate
Januel C et al
Sun Exposure - Too much exposure to the UV rays causes darkening of lips if you don't follow sun protection or at least apply spf Biting of Lips - Constantly biting or licking lips can also cause discoloration and irritation
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