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This means that if you inject 5 mg of tirzepatide on Monday: By Saturday (day 5), approximately 2.5 mg equivalent remains in circulation By the following Monday (day 7), approximately 1.9 mg equivalent remains When you inject the next 5 mg dose on Monday, it adds to the 1.9 mg still circulating By week 4 of consistent weekly dosing, you reach steady state, where the amount you inject each week equals the amount eliminated