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doi: 10.14639/0392-100X-N0139

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Trials assessing combinations of GLP-1 agents with GIP agonists and/or GCGR antagonists have proven to effectively produce both significant weight loss results and improvements in adjacent therapeutic areas

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Nowadays, FOXO4-DRI studies are focused on the following aspects: osteoarthritis (senescent chondrocyte clearance), metabolic dysfunction (insulin resistance and obesity-associated senescence), neurodegeneration (eliminating senescent brain cells), and fibrotic diseases (idiopathic pulmonary and liver fibrosis)