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Available from: Ahmadi H, Fotesko K, Ba-Ali S, Hamann S, Kolko M
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In a cerebrospinal fluid (CSF) substudy, participants receiving semaglutide exhibited modest yet statistically significant reductions (in the range of 10% or less) in several key biomarkers associated with Alzheimers disease (AD) pathology and neurodegeneration, including phosphorylated tau181 (p-tau181), phosphorylated tau217 (p-tau217), total tau, and the neuroinflammatory marker YKL-40 levels
Newman, E
The studies conducted by Mansur et al 23 and Li et al 22 and their respective findings on liraglutides effect on cognitive function are promising, as they observed improvements in cognitive scores and memory, along with enhanced brain activation, indicating the potential neurocognitive benefits of GLP-1 agonists