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Cathepsin B, a cysteine protease presents in the late endosome and lysosome compartments in mammals, is also overexpressed in many cancer cells

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Its mechanisms is closely related to the ROS levels, for example, moderate levels of ROS can activate the autophagy process, while excessive ROS may lead to cell damages [255]

This project was supported in part by NIH Public Health Service grant P30DK056338, which funds the Texas Medical Center Digestive Diseases Center and P30CA125123, which funds the Baylor College of Medicine (BCM) Proteomics Core and its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institute of Diabetes and Digestive and Kidney Diseases, National Cancer Institute or the NIH

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